651
UCLA_CCN_APOE_DTI
APOE-3_16
HarvardOxford_110
file
file
file
file
DTI
Public
Siemens Allegra 3T
30 diffusion weighted volumes with gradient vectors taken from the International Consortium for Brain Mapping protocol, 5 B0 volumes, b = 800 s/mm2, axial slicing, repetition time (TR) = 7300 ms, echo time (TE) = 95 ms, k-space matrix = 96 × 96, slice thickness = 2.5 mm, 55 slices with no gap, field of view = 240 mm2, and voxel size = 2.5 mm3.
61.82
61.82
Female
APOE 3/3
1
DTI tractography in two steps: 1) BedpostX used to obtain first + second dyad vectors, 2) Diffusion Toolkit use for tractography using first and second vectors with FACT algorithm, maximum 50 degree turn angle Harvard Oxford cortical/subcortical masks registered to subject DTI space, thresholded at 10% Connectivity matrix generation with UCLA Multimodal Connectivity Package, excluding fibers less than 5mm For paper, graph distance matrices were multiplied by average fiber length between regions
Brain network local interconnectivity loss in aging APOE-4 allele carriers. JA Brown et al. (2011). PNAS. doi: http://dx.doi.org/10.1073/pnas.1109038108 This work was supported by National Institutes of Health National Research Service Award 1F31AG035438-01 (to J.A.B.); by National Institutes of Health Grants P01-AG025831, AG13308, P50 AG 16570, MH/AG58156, MH52453, AG10123, and M01-RR00865; by the Department of Energy (Contract DE-FC03-87-ER60615); by the General Clinical Research Centers Program; by the Fran and Ray Stark Foundation Fund for Alzheimer’s Disease Research; and by the Ahmanson Foundation.

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