| 3004 | |
| UCSF_MAC_PSP | |
| HC_7_t2 | |
| Gardner_27 | |
| file | |
| file | |
| file | |
| file | |
| fMRI | |
| Public | |
| Siemens Trio 3T | |
| acquisition time=8 min 06 sec, axial orientation with interleaved ordering, field of view=230 x 230 x 129 mm, matrix size=92 x 92, effective voxel resolution=2.5 x 2.5 x 3.0 mm, TR=2000 ms, TE=27 ms | |
| 77.39 | |
| 77.39 | |
| Male | |
| Control | |
| 1 | |
| For each fMRI scan, the first five volumes were discarded. SPM12 (http://www.fil.ion.ucl.ac.uk/spm/software/spm12/) and FSL (where explicitly specified; http://fsl.fmrib.ox.ac.uk/fsl) software was used for subsequent fMRI preprocessing. The remaining 235 volumes were slice-time corrected, realigned to the mean functional image and assessed for rotational and translational head motion. Volumes were next co-registered to the MP-RAGE image, then normalized to the standard MNI-152 healthy adult brain template using SPM segment, producing MNI-registered volumes with 2 mm3 isotropic resolution. These volumes were spatially smoothed with a 6 mm radius Gaussian kernel and temporally bandpass filtered in the 0.008-0.15Hz frequency range using fslmaths. Nuisance parameters in the preprocessed data were estimated for the CSF using a mask in the central portion of the lateral ventricles and for the white matter using a mask of the highest probability cortical white matter as labeled in the FSL tissue prior mask. Additional nuisance parameters included the 3 translational and 3 rotational motion parameters, the temporal derivatives of the previous 8 terms (WM/CSF/6 motion), and the squares of the previous 16 terms (Satterthwaite et al., 2013, doi:10.1016/j.neuroimage.2012.08.052). All subjects had maximum relative head motion less than 3mm, maximum relative rotation less than 3 degrees, and the maximum number of motion spikes (relative motion > 1 mm) less than 10% of the total number of frames.
Network connectivity in the rMT was determined by taking regional masks for the 27 nodes comprising the rMT-anchored network (Gardner et al., 2013, doi:10.1002/ana.23844), applying them to a given subject’s preprocessed tf-fMRI data to extract regional mean timeseries, and partially correlating those timeseries in a pairwise fashion again controlling for the 32 nuisance parameters to obtain the 27x27 connectivity matrix. | |
| NIH grants R01AG038791, U54NS092089, P01AG019724, and the Tau Research Consortium. | |
| 3T | |
| 2 | |
| 27 | |
| 2.5x2.5x3 | |
| 230x230x129 | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
