| 661 | |
| UCLA_CCN_APOE_DTI | |
| APOE-4_6 | |
| HarvardOxford_110 | |
| file | |
| file | |
| file | |
| file | |
| DTI | |
| Public | |
| Siemens Allegra 3T | |
| 30 diffusion weighted volumes with gradient vectors taken from the International Consortium for Brain Mapping protocol, 5 B0 volumes, b = 800 s/mm2, axial slicing, repetition time (TR) = 7300 ms, echo time (TE) = 95 ms, k-space matrix = 96 × 96, slice thickness = 2.5 mm, 55 slices with no gap, field of view = 240 mm2, and voxel size = 2.5 mm3. | |
| 45.83 | |
| 45.83 | |
| Female | |
| APOE 3/4 | |
| 1 | |
| DTI tractography in two steps: 1) BedpostX used to obtain first + second dyad vectors, 2) Diffusion Toolkit use for tractography using first and second vectors with FACT algorithm, maximum 50 degree turn angle
Harvard Oxford cortical/subcortical masks registered to subject DTI space, thresholded at 10%
Connectivity matrix generation with UCLA Multimodal Connectivity Package, excluding fibers less than 5mm
For paper, graph distance matrices were multiplied by average fiber length between regions | |
| Brain network local interconnectivity loss in aging APOE-4 allele carriers. JA Brown et al. (2011). PNAS. doi: http://dx.doi.org/10.1073/pnas.1109038108
This work was supported by National Institutes of Health National Research Service Award 1F31AG035438-01 (to J.A.B.); by National Institutes of Health Grants P01-AG025831, AG13308, P50 AG 16570, MH/AG58156, MH52453, AG10123, and M01-RR00865; by the Department of Energy (Contract DE-FC03-87-ER60615); by the General Clinical Research Centers Program; by the Fran and Ray Stark Foundation Fund for Alzheimer’s Disease Research; and by the Ahmanson Foundation. | |
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